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Once formed, NO in the PVN activates yet unidentified intracellular targets, apparently different from guanylate cyclase (i.e., ADP-ribosyl-transferases and other iron-containing enzymes [4,12,26]), which in turn lead to the activation of oxytocinergic neurons mediating the appearance of the sexual response by releasing oxytocin in sites distant from the PVN, i.e., the ventral tegmental area, hippocampus, amygdala, ventral medulla and the spinal cord [40,53,54,56,57]. In the PVN NO is synthesized by NO synthase located in the cell bodies of oxytocinergic neurons projecting to extra-hypothalamic brain areas and mediating this sexual response. 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