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Nevertheless, it is essential to acknowledge that the current evidence related to children and the long-term effects of dietary interventions remain limited, necessitating cautious interpretation. This review highlights the potential of microbiota plasticity as a promising avenue for disease prevention and treatment, with the KD showing potential in influencing various diseases and underlying mechanisms. Despite any stance, then, these data show how KD has direct involvement with and may modulate the colonic microbiota. KD could then influence the brain not only directly through GABA-mediated mechanisms, but even by microbiome metabolites and short chain fatty acids. Moreover, short chain fatty acids, principally produced by Firmicutes, Akkermansia, and Lactobacillus, have been found to significantly improve the ketosis in infants on KD [78,107]. 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