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Adherence was assessed using daily blood ketone levels measured by a portable meter at home as well as at follow-up study visits, with levels averaging more than 1.0mmol/l during the period of maximum ketosis. Although both diet groups showed improvements in motor and nonmotor symptoms on the International Parkinson’s and Movement Disorders Society UPDRS rating scale, patients in the ketogenic diet group showed greater improvements in nonmotor symptoms. Of the nine patients who withdrew from the study, three withdrew for diet-related difficulties (two in the ketogenic diet group). Eighteen of the 24 patients randomized to the ketogenic diet arm completed the study (25% attrition rate). To evaluate adherence, urinary ketosis was assessed using urine dipsticks with mean morning and evening levels of urine ketone production in the diet group of 2.9 mmol/l [95% confidence interval (CI) 1.6–4.1] and 5.9 mmol/l (95% CI 2.2–8.0), respectively. Carb, carbohydrate; g, grams; KD, ketogenic diet; KDT, ketogenic diet therapy; MAD, modified Atkins diet; NR, not reported; Obs, observational study; Pts, participants; RCT, randomized controlled trial. Although ketogenic diet therapy (KDT) has been in use for nearly one century for the management of epilepsy, the last two decades have seen a surge in clinical interest in using KDTs in the fields of neurology, oncology, obesity, diabetes, and performance enhancement, among many others. More ‘relaxed’ or modified variant forms of the ketogenic diet have emerged over the last 20 years to decrease rigidity and improve compliance. Therapies targeting nutritional ketosis without comprehensive diet modification improve cognition and cerebral blood flow in Alzheimer’s disease patients. Individual responses to ketogenic diets and supplements vary greatly, highlighting the importance of personalized approaches and professional guidance. 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