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It should also be noted that there is no particular reason to believe that long-term treatment with testosterone in younger men with chemical testosterone deficiency with or without symptoms represents a greater or lesser long-term risk in terms of adverse effects on the prostate or the cardiovascular system than treatment beginning in older men. The data at present do not support the concept that testosterone is a risk factor (24) for development of prostate cancer, but Cunningham and Toma correctly argue that inadequate data are available to determine whether long-term testosterone treatment will increase the risk of either benign or malignant prostate disease. Thus, cardiovascular disease risk and testosterone treatment in older subjects require a longer, large-scale, adequately powered study (23). Details about publication year, authors, design of the study, country, sample size, age of the patients, interventions, and outcomes of the study were extracted from each included study. 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