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PDE-5 catalyses the breakdown of the smoothmuscle-relaxing agent, cyclic guanosine monophosphate (cGMP), a second messenger ofnitric oxide.10 In the body, inhibition ofPDE-5 increases cGMP levels, reduces intracellular calcium (Ca2+) andinduces vasodilation.10,11 The drugs possess identical mechanisms of action, but differessentially in their duration of action and in some aspects of their pharmacokineticprofiles. The technique was based on penile lipofilling combined with V-Y infrapubic skin plasty and SLR. Several authors reported outcomes of SLR in the context of a congenital intrinsic penile shortness (Table S9.5 online supplementary evidence Appendix 5). The surgical access is via an infrapubic incision and may be combined with an elongating V-Y skin plasty . The broad spectrum of surgical interventions described to manage AABP is summarised in Table S9.3 in online supplementary evidence Appendix 5. 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