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Although some research reported that sugar/sweeteners type did not significantly influence textural properties , other research discovered that the type of sugar used would affect hardness levels . Because each kind of gummy was made with the same gum base, their different texture properties may be due largely to the differences in sweetener used in the gummy. Accordingly, gummy dosage forms in this study significantly improved blood glucose control. It has been explained by McClements that gummies contain hydrocolloids that may increase the viscosity of the gastrointestinal fluids, thereby slowing the mixing and mass transfer process, and altering the flavors or nutrients release . Since the available carbohydrates were same in each group, the difference in GI values is likely due to texture differences and subsequent digestive behavior differences among different kind of gummies. All three types of gummies can slow the post-prandial rise in blood glucose and were low-GL foods when not taken in excessive amounts. Based on Figure 3, only a small amount of glucose was released after 5 min SSF incubation for all gummy samples. Texture profile analysis parameters (TPA) of the three types of gummies (Mean ± SD). Additionally, CG had a significantly lower gumminess and chewiness compared with other two gummies. The common link between these patients was the use of an ED supplement that contained glyburide (a sulfonylurea used to treat diabetes), as well as illicit PDE-5i (31). In a well-known example, 150 non-diabetic patients were hospitalized with hypoglycemia in Singapore. Furthermore, 11.5% of patients being evaluated for a PDE-5i prescription had a new underlying disease detected (26). Before PDE-5i are prescribed, patients must be evaluated for potential drug interactions and warned of the absolute contra-indications. 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