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However, treatment with Cis remarkably improved the histology of hypobaric hypoxia-induced testicular damage in vivo (Figure 4A). The enzymatic mechanism inhibiting OS involves free radical scavengers such as glutathione reductase (GR), glutathione peroxidase (GPx) and superoxide dismutase (SOD) . In addition, the ratio of Bax/Bcl-2 was higher in the model group than in the control group, and Cis treatment reduced the ratio of Bax/Bcl-2 (Figure 3D). 385) Parmanand, Bhavika, et al. "Systemic iron reduction by venesection alters the gut microbiome in patients with haemochromatosis." JHEP Reports (2020) 381) Jo, Hyung Ah, et al. "Fumarate modulates phospholipase A2 receptor autoimmunity-induced podocyte injury in membranous nephropathy." Kidney International (2020). 375) Han, Yumei, et al. "Urine metabolomic responses to aerobic and resistance training in rats under chronic unpredictable mild stress." 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