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It is plausible as a result that the equivocal findings in respect of CM ingestion and exercise performance could also be partly attributed to the amount of ingested citrulline being lower than intended. Few studies investigating exercise performance have included concomitant measurements of peak plasma citrulline, which is likely due to the cost of such procedures. Sildenafil 100 mg improved the sexual experience and treatment satisfaction, and reduced feelings of anxiety compared with the 50-mg dose. Measures of treatment satisfaction and sexual experience significantly favored the 100-mg dose compared with the 50-mg dose in the DBPC. No serious sildenafil-related adverse events occurred in clinical trials; cardiovascular events seen in postmarketing surveillance generally occurred in patients with other known risk factors. Sildenafil also appears to improve the quality of life of both patients and their sexual partners. 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