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After administration to the meatus and glans of the penis, alprostadil is rapidly absorbed through collateral vessels into the corpus spongiosum and corpora cavernosa, and the on-set of erection is likely to occur within 5–30 min. The rationale for topical delivery is based on the potential to administer a vasoactive substance without the (potentially) systemic adverse effects of oral therapy and the invasive, uncomfortable nature of the intracavernosal or intraurethral route. VITAROS offers the combination of the active drug with a skin penetration enhancer, namely dodecyl-2-N,N-dimethylamino propionate (DDAIP), that improves local absorption of the active compound at the site of administration. At 14 to 30 months, the combination therapy was still favored by the patients and used regularly [57,58]. Due to its ease of administration, it provides patients with a higher quality of life versus the intracavernosal self-injection regimen [55,56]. 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