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These studies often use similar techniques (e.g., trapping or mist-netting, collecting a blood sample, and radioimmunoassays or enzyme immunoassays for quantifying hormone titers) and behavioral measures (e.g., simulated territorial intrusions and scan or focal sampling for measurements of aggression). Aggressive behavior is influenced by a complex array of psychological, environmental, and physiological factors, including circulating levels of the endogenous sex hormone testosterone (T). In two large surveys, 23–32% of PDE-5i users had no prior interactions with healthcare professionals (13,14). Besides the high profit margins, the underlying characteristics of consumers of PDE-5i make it a prime target for counterfeiters. In fact, for PDE-5i, the illegal market in industrialized countries approaches the size of that in developing countries. 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