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Research on muscle activation has also shown that free weight exercise results in a greater muscle activation than machine exercise, likely by inducing a larger overall muscle mass involvement than similar machine-based weight exercises . Shaner et al. evaluated the hormonal changes with similar lower body multi-joint movement free (i.e., squats) or machine weight (i.e., leg press) exercises. Circulating T-Testo has been shown to increase immediately after a bout of heavy resistance exercise and return to baseline or even decrease beyond that level within 30 min post-exercise . These results suggest that intensity among other factors can play a role in the immediate changes in serum testosterone concentrations with endurance exercise. Hormone levels are measured to ensure dosage titrations achieve the desired circulating hormone levels. 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