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In this study, testosterone concentrations obtained at each laboratory were compared to the AMM, with testosterone values at UCSF showing the largest percent difference in values. Gel serum separator tubes have been demonstrated to be a source of interference that results in higher than actual testosterone concentrations reported by LC-MS/MS , , , and fluoride-containing tubes have been shown to result in lower than actual testosterone concentrations reported by LC-MS/MS . Immunoassays are easier to implement, and are technically simple for clinical laboratory technicians to perform; however, they suffer from a lack of specificity, especially at low testosterone concentrations found in female and pediatric patients , . Calibrators were prepared in-house using the testosterone standard spiked into the double charcoal stripped serum with concentrations assigned using the NIST SRM 971 as calibrators in four different runs in duplicate and using the mean of the calculated concentrations. 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