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Serotonin receptors have been identified in the expected locations such as the brain stem, hypothalamus, and spinal cord, as well as ejaculatory structures including the prostate, seminal vesicles, vas deferens, and urethra (15-17). In all, the seminal vesicles contribute 65-75% of the ejaculate volume, the prostate contributes roughly 25-30%, vasal fluid supplies 5-10%, and finally bulbourethral glands contribute less than 1% of the total ejaculate volume (Table 1) (3,4). As noted prior, some yellowing of the semen can occur naturally with any accumulation of lipofuscin in seminal fluid, whether due to the individual’s age, time spent abstinent from ejaculation, or other benign etiologies, including retained urine in the urethra . This is due to the secretions of the prostate and seminal vesicles rather than the sperm component.[3••, 14] A mild gradual yellowing of the semen is normal with age and/or prolonged abstinence from ejaculation. 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