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The production of IgE induced by the allergen is the main process leading to an allergic reaction, and IL-6 and IL-8 can stimulate the secretion of IgE by promoting the differentiation of acidic granulocytes. Even though this canonical division of labor is true for a number of neuronal types in the mammalian brain (including neocortical and hippocampal pyramidal neurons or cerebellar Purkinje neurons), many neuronal types do not comply with this classical polarity scheme. Overall, these high-resolution electrophysiological studies on neurotransmitter release revealed that a presynaptic action potential is tightly coupled to Ca2+ influx and synaptic vesicle fusion, such that under physiological conditions, Ca2+ triggers fusion in a few hundred microseconds, or possibly even in less than 100 microseconds (Sabatini and Regehr 1996). 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