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Contact your health-care provider immediately if you suspect that you have a medical problem. You should not use this information as self-diagnosis or for treating a health problem or disease. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. For additional information about a product, please contact customer service. There is increasing interest in botanic dietary supplements containing yohimbine extracts in the context of sexual and body enhancement . In fact, ginseng toxicity mainly comes from drug interactions with cytochromes P450 (CYPs) CYP3A4 and CYP2D6 inhibitors and serotoninergic drugs, intensifying sedative effects or inducing cognitive disorders or a serotonin syndrome [229,230,231]. A few cases of headache following ginseng administration were reported without placebo control [84,91]. 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"RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients." (2022). "Effects of American fruit extracts on antioxidant-related genes in cultured cells & on modulation of metabolomic profile in poultry." (2022). "Integration of transcriptomics and metabonomics revealed the protective effects of hemp seed oil against methionine–choline-deficient diet-induced non-alcoholic steatohepatitis in mice." Food & Function (2023). "Seasonal variations in the metabolomic profile of the ovarian follicle components in Italian Mediterranean Buffaloes." Theriogenology (2023). "Serum and milk metabolites of Holstein dairy cattle for the establishment of objective indicators in a subacute ruminal acidosis-induced." Animal bioscience. 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