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Furthermore, in instances of unclear information in included studies, clarification was soughtby emailing the relevant studies’ corresponding authors. PICO (participants, intervention/exposure, comparison, outcomes, and study design) criteria for inclusion and exclusion of studies After excluding duplicate studies, two authors (AH and MP) independently reviewed articles based on titles, abstracts, or full-texts to identify relevant studies. Additionally, the reference lists of related review articles and the retrieved studies were also hand-searched to detect eligible trials that might have been missed. The search keywords were seldom based on vinegar and related phrases to minimize the chance of missing studies which reported lipids or glycemic related markers as secondary outcomes. Therefore, in the current study, we performed a systematic review and meta-analysis of all published clinical trials to provide a more precise estimation of the effects of ACV on serum lipid parameters and glycemic markers in adults. To the best of our knowledge, there has been no systematic compilation of the previously reported effects of ACV on lipid profiles and glycemic status. Indeed, some investigations have reported beneficial effects following ACV consumption on the aforementioned parameters [16, 22, 23, 27], although others failed to detect any effects [4, 12, 33]. The effects of ACV on serum lipid parameters and glycemic markers have been investigated in several randomized clinical trials [4, 12, 16, 22, 23, 27, 33]; however, the results are equivocal. ACV contains a variety of flavonoids, such as gallic acid, catechin, caffeic acid, and ferulic acid [11, 31]. This acidic solution is consumed throughout the world as a flavoring and preservative agent in foods . In contemporary research and practice, plants and their derivatives have attracted a lot of interest for their beneficial effects in controlling lipid profile and glycemic status [5, 15, 37]. In this line, the benefical effect of nutraceutics and fuctional foods on human health have been well-documented [8, 36]. Lifestyle modifications (dietary changes and physical activity), along with pharmacological interventions, such as statins, fibrates, and insulin sensitizers, are routinely used to manage these metabolic disorders [1, 14, 19, 26]. Indeed, given the high economic costs of CVDs on healthcare systems, especially in developing countries, prevention and management of CVDs is of high priority. 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Empirical Analysis.We further conduct empirical studies to present the impact of prompts on task performance.To conduct the experiments, we select a variety of tasks that span language generation, knowledge utilization, complex reasoning, structure data generation, and information retrieval.For each task, we manually write a prompt that follows general guidelines introduced above. However, most of these approaches are tested on small-sized pre-trained language models, instead of the LLMs.So far, there still lacks a thorough investigation on the effect of different efficient tuning methods on large-sized language models at different settings or tasks. 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