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On the other hand, the administration of a macamide (benzyloctadecadienamide) showed greater inhibitory potency of soluble epoxide hydrolase (sEH) and better bioavailability than other macamides, as well as persistent antinociceptive effects for more than 6 h (Singh et al., 2020). Finally, the hydroalcoholic extract in BPH showed a decrease in prostate stromal mass and area, and inflammatory cells (neutrophils, lymphocytes, mast cells); suggesting an inflammatory regulation promoted by the Th2 lymphocyte pathway due to the increase in anti-inflammatory cytokines (IL4, INF-γ) and decrease in a proinflammatory cytokine (TNF-α) (Vásquez-Velásquez et al., 2020). On the other hand, the methanolic extract in pulmonary fibrosis was shown to decrease histological alterations, bronchoalveolar cell count and levels of pulmonary LDH and MDA, having a greater effect than prednisone in the latter marker (Ruiz Toledo et al., 2018). 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