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Information on gastric cancer risk needs to be determined for the supplement forms of these ingredients, and more data are needed to understand if a protective effect exists at lower levels. Similarly, more recent meta-analyses have shown inconsistent relationships but have evaluated the whole food and not supplements [147,148]. A tolerability study of a proprietary product comprising of a blend of capsaicinoids obtained from Capsicum annuum has been reported as well and showed no change in tolerability at ≤500 mg/day (10 mg/day of capsaicinoids) when provided for 1 week . Eight of the 10 studies using supplements reported adverse events, with six indicating no adverse events during the study . For example, a meta-analysis of metabolic syndrome clinical studies providing capsaicinoids ranging from 2–9 mg/day for 4–12 weeks combined food and supplement sources noted no serious adverse events and no events leading to withdrawal were reported in the studies . 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