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Subjects followed a diet plan which cycled between shorter periods of a ketogenic Mediterranean diet followed by longer periods of a traditional Mediterranean diet. Ketosis is thought to alter metabolic pathways to induce weight loss and potentially improve other health outcomes, such as a reduction of hyperglycemia and improvement in lipid profiles. Over the past few decades, many studies have sought to quantify the efficacy of low carb diets in terms of weight loss as well as evaluate the potential for amelioration of chronic disease. While the details of low-carbohydrate diets may have changed, they have remained a mainstream option for weight loss. 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