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This increase in aldosterone, with the direct association of the presence of ketone bodies, would strongly indicate a direct mechanistic link between the metabolic state of ketosis, induced by KDs, and an increase in aldosterone production. The relationship between the KD and drugs acting on the renin–angiotensin–aldosterone system (RAAS) is a very promising research field, especially for dietary interventions and their endocrine effects. Et al. suggested that ketone bodies produced by the KD may have various beneficial impacts on cardiovascular health. Urinary tract infections and diabetic ketoacidosis (DKA) are the most prevalent adverse effects . Sodium-glucose cotransporter-2 (SGLT-2) inhibitors, commonly referred to as gliflozins or flozins, are medications used extensively to treat type 2 diabetes (T2D) owing to their benefits in reducing glucose levels and improving cardiovascular and renal function . Evidence from cellular and preclinical studies supports the drug’s potential for cancer treatment. Although highly acknowledged for its beneficial effects on health and in managing chronic conditions, the KD can cause severe health problems if followed without surveillance. Furthermore, KB affects ion channels and neurotransmitter carriers, impacting the glutamate-to-ketone percentage and potentially decreasing epileptic events [27,28]. Moreover, reducing dietary carbohydrates through the KD hinders the production of cholesterol, which is influenced by insulin and plasma glucose levels . During a shortage of glucose, the energy focus switches from glycolysis to the breakdown of fatty acids . Changes in lipid metabolism are notable when following the KD, with a common focus on its effects on blood lipids. 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