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A somewhat less energetically favorable binding pose for testosterone binding to CYP3A4 was also observed, orienting testosterone for a 2β attack by the activated oxygen species (Fig. 7B). The most energetically favorable binding pose found for docking testosterone into the CYP3A4 structure positioned the testosterone C6 atom approximately 5.97 Å away from the heme iron, with the Fe-6βH-C6 angle equal to 115° (optimal angle, 180° ± 45) (Szklarz and Halpert, 1997) (Fig. 7A). In an effort to obtain a better understanding of the structural elements of each individual enzyme involved in ligand binding, we performed an in silico docking study with testosterone and the respective enzyme receptors using the UCSF DOCK 6.7 software suite. Gynecomastia Surgery Florida Male Breast Reduction Experts Refined Carbs Impact On Insulin And Testosterone When combined with a healthy diet and exercise plan, Plenity has the potential to complement your weight loss results. 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