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Several studies have reported a high success rate of vacuum devices in achieving erection in patients and satisfactory sexual intercourse with their partner in ED of various etiology (psychogenic, spinal cord injury, diabetes mellitus, prostatectomy and other organic causes) [244,245,246,247,248,249,250]. The facilitatory role of oxytocin on erectile function and sexual behavior was discovered in 1985, when t peptide was found to be able to facilitate male sexual behavior in rodents when injected systemically and induce penile erection when injected into the lateral ventricles or into the PVN of male rats at doses as low as 3 ng (e.g., 3 picomole) [151,152,153]. In contrast to the detailed knowledge of local mechanisms controlling the tone of cavernous smooth muscles, at the central level, very little is known of the neural pathways conveying sexual information from the brain to the genital apparatus to induce penile erection even if a few brain areas involved in erectile function have been identified. The sexual benefits of supplementation in men with low serum testosterone primarily pertains to libido but mild improvements in erectile function in patients may occur with testosterone supplementation alone (53). It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The opinions expressed are the author's alone and have not been provided, approved or otherwise endorsed by our advertisers. 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