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Scarce progress in the therapy of ED has also been obtained with the LI-ESW therapy since its first application for ED in 2010, reporting the improving effect of this method on cavernous hemodynamic disorders with no adverse effects . Not much better results have been obtained with stem cells modified or supplemented with angiogenic and/or neurotrophic genes, proteins such as those present in platelet-enriched plasma and with the intracavernous injection of platelet-enriched plasma itself, or stem cells bioengineered with particular substances (i.e., hydrogels), aimed to facilitate stem cell adherence and implant in damaged penile tissues to improve their therapeutic efficacy [206,213,214207,214,215). Pruriens seed produced a significant and sustained increase in the sexual activity of normal male rats at a particular dose (200 mg/kg). Globally, only the hexanic fraction significantly improved the majority of the sexual parameters measured. 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