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NMR analysis of the human saliva metabolome distinguishes dementia patients from matched controls. NMR based urinary profiling of Lactulose/Mannitol ration used to assess the alterd intestinal permeability in acute on chronic liver failure（ACLF）patients. 90) Pertinhez TA, Casali E, Zambianchi L, Spisni AStatistical validation of 1H NMR protocol vs standard biochemical assay in quality control of RBC packed units. 12) Martínez-López FJ, Bañuelos-Hernández AE 1 H NMR metabolomic signatures related to giant cell tumor of the bone RSC Advances, 2017. Evaluation of targeted and untargeted effects-based monitoring tools to assess impacts of contaminants of emerging concern on fish in the South Platte River, CO[J]. 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The third, aerobic or oxidative metabolism, involves the combustion of carbohydrates and fats, and only in a few cases of proteins, in the presence of oxygen . One of the main short-term side effects of the KDs is the so-called “keto flu” , also often referred to as “keto-induction” or “keto-adaptation” [21,22], a cluster of transient symptoms generally reported as occurring within the first few weeks of KD, predominantly constipation, headache, halitosis, muscle cramps, diarrhoea, vomiting, and general weakness . Therefore, when fasting is prolonged and glycogen reserves are depleted, in order to supply the unavailable dietary glucose, the gluconeogenesis process is stimulated, and the primary carbon skeletons required for the synthesis of glucose come from lactic acid, glycerol, and the amino acids alanine and glutamine . Focusing on diet, different recommendations emphasize the need to increase or avoid consumption of entire classes of food, with only partly known and only partly foreseeable consequences on the overall level of health. Low carbohydrate diet decreases myocardial insulin signaling and increases susceptibility to myocardial ischemia. Ketone body metabolism in diabetic and non-diabetic heart failure. Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics. Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41. Dietary carbohydrates restriction inhibits the development of cardiac hypertrophy and heart failure. Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice. Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats. 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