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In all cases we found that the measurements were coherent with the morphometric values of reference of adult men according to Wessels and Ponchietti9,12 and this information was shared with the patients. The circumference of the penis was measured at rest at mid-shaft. All patients signed the informed consent to undergo the procedure and for the video to be published. Classical NO donors (i.e. organic nitrates) have shown poor efficacy in treating ED and carry the risk of side effects secondary to nonspecific interaction of NO with other biological molecules. Since PDE5I are NO-dependent, they have shown unsatisfactory results in various subpopulations of patients who lack endogenous NO supply. In China, horny goat weed, or Epimedii herba has been used for centuries to enhance sexual drive and performance. A Phase IIa trial to assess the safety, tolerability and efficacy of different single doses in ED patients known to respond to PDE5I was completed. 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