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In a separate drug interaction study, when amlodipine, 5mg or 10 mg, and VIAGRA, 100 mg were orally administered concomitantly tohypertensive patients mean additional blood pressure reduction of 8 mmHg systolic and 7 mmHg diastolic were noted [see DRUG INTERACTIONS and CLINICALPHARMACOLOGY]. PDE5 inhibitors, including VIAGRA, andalpha-adrenergic blocking agents are both vasodilators with blood pressurelowering effects. The recommended dose for ritonavir-treated patients is 25 mg prior to sexual activity and the recommended maximum dose is 25 mg within a 48 hour period because concomitant administration increased the blood levels of sildenafil by 11-fold [see WARNINGS AND PRECAUTIONS, DRUG INTERACTIONS, and CLINICAL PHARMACOLOGY]. 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