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This hypothesis was supported in thecurrent study, as a post hoc analysis of trial data revealed an average 4.8%improvement in fatigue during the first phase of the study in shift/mine workerscompared to a larger improvement of 12.6% in the remaining participants. This increases the likelihood of floor effects, and asonly moderate improvements are likely, larger sample sizes would be required toidentify statistically significant differences. Anti-stress and antidepressant effects of ashwagandhahave also been observed in animal studies comprised of unpredictable foot shock,elevated plus-maze test, and the forced swim test (Bhattacharya, Bhattacharya, Sairam, & Ghosal,2000; Bhattacharya& Muruganandam, 2003). Mean salivary hormone levels during each crossover period are detailed inTable 3 andFigure 3. Exposure to certain chemicals and lifestyle factors can negatively impact testosterone levels. 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