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However, the post hoc analysis of the difference in the mean change from baseline in T3 levels between the placebo and test supplement is limited in that it was inadequately powered to detect a change in T3 between treatment groups. For these reasons, addition of the test supplement to standard care is a possible treatment strategy, as has been demonstrated in a recent study showing improvement in fibromyalgia symptoms with administration of the test supplement in addition to standard care in individuals with fibromyalgia.44 Consistent with previous results,27 no adverse tolerability or safety findings were observed in any studies. In this study, we report that the increase in hGH previously demonstrated27 after administration of the test supplement likely occurs through inhibition of somatostatin. 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