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The combination of healthy fats and low carbohydrate content in keto gummies can provide a satisfying treat that helps curb hunger and promotes satiety. Keto gummies are marketed as a delicious way to supplement the ketogenic diet and aid in achieving and maintaining ketosis. Thus, it is likely that acetic acid is ketogenic, and has additional benefits for overall metabolic health, however, no research has been performed on acetic acid and its specific effects on the induction of ketosis or mitigation of keto-induction symptoms in humans. Very-low-carbohydrate ketogenic diets (VLCKDs) are becoming increasingly popular for mainstream and athletic use for a range of outcomes including weight-loss and maintenance (Bueno et al., 2013), improved satiety and a reduction in hunger (Paoli et al., 2015; McClernon et al., 2007; Johnstone et al., 2008). 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Hyperuricaemia and dyslipidaemia are co‐morbidities commonly seen in subjects seeking a KD for weight loss purposes, but they may be exacerbated by it due to the relative increase in protein intake and the variable dietary fat depending on the approach to achieve nutritional ketosis, despite not being listed as absolute contraindications according to available recommendations. The ketogenic diet (KD) is defined as a dietary manipulation characterized by a very low carbohydrate content (5%–10% of total daily calorie intake, or 20–50 g per day1, 2), but the macronutrient composition may vary, defining different ways to reach nutritional ketosis. First identified as a feasible treatment for intractable epilepsy, the ketogenic diet (KD) has recently gained popularity thanks to growing evidence on applications such as weight loss, most importantly, but also NAFLD, cancer, neurologic conditions and chronic pain. 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The prevalence of obesity in the United States remains a significant public health issue, as nearly one-third of men and women are classified as overweight or obese . Furthermore, ketosis can be classified into “physiological ketosis,” which occurs during fasting or exercise, and “nutritional ketosis,” induced by nutritional or supplementation strategies. Ketone body concentration is elevated during periods of nutrient deprivation or low carbohydrate availability, such as fasting/starvation , exercise , or diabetes [16,17], encompassing both physiological and pathological conditions. However, ketone bodies are present in the circulation during fed and fasted conditions, although serum concentrations are generally low under basal conditions, typically 0.1 to 0.4 mM in humans and rodents. 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