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Another limitation in the study is the lack of measurements of albumin levels which is included for calculation of free testosterone, because of limitations of available serum volume. The agreement between the algorithms may differ in a clinical setting with patients exhibiting extreme values of binding proteins and/or total testosterone levels where a more comprehensive model incorporating dynamic repartitioning of testosterone between SHBG and albumin bound fractions may be superior. In the present study, free testosterone was calculated in men from the general population with only a minor proportion of the men being characterized by extreme hormone levels. A 2009 study has shown that D-aspartic acid can increase LH levels in men and women.4 In men, it signals the testes to produce testosterone. 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