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The primary purpose of this literature review was to critically assess the physiologic effects of vitamin D supplementation on serum testosterone concentrations in men and the secondary purpose was to evaluate the feasibility of vitamin D status toward urologic health (testis and prostate). We, therefore, aimed to evaluate whether vitamin D supplementation increases serum total testosterone (TT) levels in men with low TT levels at baseline. In a recent cross-sectional study of women, researchers observed a positive, significant correlation between serum 25(OH)D concentrations and total testosterone levels. Suggestions that serum testosterone levels are due to the effects of vitamin D on Leydig cell calcium homeostasis, aromatase activity, osteocalcin, or the activity of extragenic vitamin D6,9,38,39,40,41 are preliminary and require further study. 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