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WAKE-UP and THAWS applied the DWI-FLAIR mismatch concept and randomized patients if MRI showed a mismatch between an acute ischemic lesion that was visible on DWI while there was no marked parenchymal hyperintensity on FLAIR based on visual judgement, indicating an ischemic lesion age of less than 4.5 hours and the absence of severe and irreversible tissue damage 5. The trials included in this meta-analysis differed in design and imaging inclusion criteria but they all relied on imaging biomarkers beyond non-contrast CT and vessel imaging. Industry propagandists, their lobbyists and right wing think tanks feel free to make the most outrageous claims about the animal rights movement, unburdened by any need to provide evidence. With very few exceptions, animal activists have not engaged in violence against humans. While animal activists have not directed violence against humans, some have engaged in intimidation. 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