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Moreover, in patients with ED, particularly in middle-aged and elderly patients, dynamic PDU may also provide a predictive response for the potential effectiveness of the vasodilative drugs used for ED, as demonstrated by the negative correlation between the severity of penile vascular damage and the clinical response to treatment with PDE5i . Furthermore, dynamic PDU has a crucial role in the differential diagnosis between psychogenic and the most common form of organic ED, namely vasculogenic ED, in patients of different ages ; in particular, dynamic PDU has been reported to have a more specific diagnostic value for recognizing or excluding vasculogenic ED in the setting of constitutive severe anxiety-affected young patients, which despite a pathological PSV in flaccid state due to an exaggerated sympathetic tone, might reach a normal PSV value after pharmacologically induced erection, therefore overcoming a potential bias of basal PDU procedure [35,36,37]. 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