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The physiological and psychological evaluations must be considered with patients' attitudes toward surgery to analyze the feasibility and effects of surgery and determine whether these can be achieved (Fig. 2). Considering the critical role of the Ang-1/Ang-2 system in the preservation of endothelial function, it is reasonable that a glucose-induced failure of this axis could also affect the vascular bed of penile tissue thus favouring ED development. A previous in vitro study revealed that high glucose concentrations suppress the ability of Ang-1 to activate the Tie-2 receptor with the abrogation of PI3K/Akt signalling, thus reducing vascular protection . In this scenario, both hyperglycaemia and AGEs are known to exert a detrimental effect on endothelial function by impairing the angiopoitin-Tie-2 system. 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