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It was reported by Buchmann et al. that longer milling times lead to erosion from balls , which means contamination of the product. Ginseng is a vital constituent of traditional Chinese medicine and has been used to treat various physical conditions for thousands of years, importantly as an aphrodisiac and is used to treat sexual dysfunction as well as to enhance sexual behavior and gonadal functions (Fig. 1). The ginsenoside Re-induced motility enhancement effect in spermatozoa could be related to the findings that Re is found to be both ER and PR agonists.58 For example, the estrogen-induced forward movement of human spermatozoa into the oviduct could be effectively suppressed by progesterone.74-77 In addition, it was shown that progesterone, which was secreted by the culumus cells surrounding the oocyte to induce sperm hyperactivation, was inhibited in the presence of estrogen.78 On the other hand, estrogen and progesterone may cooperate to optimize their effects on fertilization.79,80 Ginseng extracts contain a mixture of ginsenosides that can activate either or both ER and/or PR, and, hence, may modulate different aspects of sperm function. 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