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Over 1 year, weight loss achieved with these drugs,above and beyond weight loss with lifestyle counseling alone, ranges approximatelyfrom 3% to 9% of initial body weight .The rate of weight loss in the first 3–4 months is the only consistentpredictor of weight loss over a year. With the understanding that long-term weight management is imperative forachieving clinically meaningful health benefits, US Food and Drug Administration(FDA) now requires demonstration of weight loss efficacy over a minimum of 1 yearfor approval of antiobesity drugs . Individuals with obesity areat greater risk of treatment-resistant and treatment-refractory hypertension[20, 21], and experience higher rates of end organ damage fromhypertension (i.e. cardiovascular disease and end stage renal disease) [4, 5],compared to normal-weight individuals. 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