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Berberine is one of the few herbal supplements with pharmaceutical-level effects. Others have shown that it’s superior for improving fasting blood sugar and fasting insulin levels . There is no single best strategy for weight management, although some evidence-based methods have been suggested (Table 1). Intermittent fasting involves regular periods with no or very limited calorie intake. Recently, fasting has received interest not only from medical experts, but also from members of the general public with an interest in health. Summary of the results reported by a meta-analysis of randomized controlled trials in adults according to dietary interventions. However, more evidence is required to confirm its effectiveness and safety.37,41,42 Similar to VLCKDs, ketogenic diet is contraindicated in pregnant women; those with T1DM, kidney failure, or cardiac arrhythmia; and in older patients with frailty. 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