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Gray et al. found adose-response relationship between T dose and visual-spatial cognition over 20 weeks inhealthy older men (212), consistent withimprovements noted in other studies of exogenous T (213). Replacement of normal elderly men with low T levels without cognitive deficits with T orT plus finasteride failed to demonstrate significant effects on cognition over 3 yearscompared with placebo, although there was a small improvement in attention with T and inverbal memory with the addition of finasteride. Although finasteride anddutasteride both can cross the blood-brain barrier (210, 211), the predominant expression ofSRD5A type 1 in the brain makes dutasteride a better agent for studying the effects of DHTinhibition in humans on cognition and mood. Alternatively, cognitive decline may be adirect cause of a reduced androgen status, a hypothesis that is contradicted by the factthat cognitive decline is not a hallmark of longstanding male hypogonadism (205). 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