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In hypogonadal men, the use of T replacement therapy (TRT) is currently well established and it is strongly recommended to induce/maintain secondary sex characteristics and to correct symptoms of T deficiency . In fact, a biochemical definition of female androgen deficiency is not completely reliable, because of the lack of standardized, accurate assays for androgens at the low levels characteristic of women and, as well, the lack of valid reference ranges . In 2014, the Endocrine Society Clinical Practice Guideline recommended against making a clinical diagnosis of androgen deficiency syndrome in healthy women, since there is a lack of well-defined criteria , as opposed to men . In particular, a subtle and progressive age-dependent decline of androgen levels has been implicated in the pathogenesis of both Hypoactive Sexual Desire Disorder (HSDD) and Genitourinary Syndrome of Menopause (GSM) , whose prevalence increases with age [3, 4]. 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