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Carbs are not strictly essential for human function; some food plans, like the ketogenic diet, intentionally eschew them in favor of converting protein and fat into energy. This, in addition to its high level of satiety, is another reason why high-protein diets are often recommended for weight loss. Another study used both male and female mice to investigate the effects of GLP‐1 receptor agonists on nicotine self‐administration, but analyses of the sex variable were not reported, and data were only shown as sexes combined (Tuesta et al., 2017). This is in line with findings from another clinical trial, investigating the effects of exenatide once weekly in patients with Parkinson's disease, where an effect on off‐medication motor scores was reported, but no significant effect on DAT availability after 48 weeks of treatment (Athauda et al., 2017). The first study—performed by our group—is a randomized, double‐blinded, placebo‐controlled clinical trial investigating reduction in heavy drinking days after treatment with exenatide once weekly for 26 weeks in patients diagnosed with AUD. Also, studies addressing the effects of GLP‐1 receptor agonists on the long‐term adaptations of the brain to high levels of alcohol consumption are needed (see Figure 1 for a summary). However, all those treatment modalities also affect food consumption (Grill, 2020), and it is therefore not clear, if the effects of GLP‐1 receptor agonists in these models can be distinguished from potential effects due to the caloric value of alcohol. Sign me up for the Weekly Diabetes & Weight Loss Newsletter (You’ll love our experts’ tips, healthy recipes and useful content) 例句如:We usually do our homework in the afternoon. Like Wegovy, it works by making you feel fuller for longer to help you better regulate your appetite. 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