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Unexplained weight loss can be due to underlying health issues such as thyroid issues, mental health illnesses, diabetes, HIV, TB, cancer, organ failure, or even as a side effect of medication (31). As mentioned above, weight loss plateaus commonly occur when your metabolism slows down during weight loss. While these medications are effective, they can lead to unintended muscle loss if not managed properly. Weight loss may not be immediate, but with consistent use of the medication and a healthy lifestyle, long-term results are achievable. GLP-1 is highly effective for weight loss when used as part of a comprehensive weight management plan that includes diet and exercise.