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Longer-term effects can include decreased bone mineral density, nephrolithiasis, cardiomyopathy, anemia, and neuropathy of the optic nerve (82, 121). In the above study, there was no effect measure modification by folic acid supplement use (115). High protein consumption facilitates hyperfiltration, a phenomenon of increased blood flow to the glomerulus, which is thought to lead to long-term damage in those with CKD (112). Other observational studies of animal protein have shown similar findings (109, 110). However, both Mendelian randomization trials and studies using HDL-elevating agents have not shown benefit regarding cardiovascular risk. In the Foster study, the standard deviation for the change in LDL-C was 20.4%, indicating that while LDL-C decreased for some, for many participants, LDL-C rose dramatically (22). In the 2002 study cited above, while the mean LDL-C increase was 18 mg/dL, one participant's LDL-C concentration increased from 123 to 225 mg/dL (91). 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The intensive behavioral therapy (IBT) intervention succeeded at week 28 in inducing a mean loss of approximately 8% of baseline weight in placebo-treated participants, a loss that declined to 5.7% at week 68, most likely because of the decreased number of counseling visits during the second part of the intervention. Let’s explore how to use protein shakes effectively to reach your goals faster! I did the 12 week shake diet (meal replacement shakes as opposed to just protein) a couple of years ago and I honestly felt great. Christa loves Fairlife’s chocolate Core Power shakes, with 26 grams of protein and 170 calories. To get belly-flattening results like Christa, use the free MyFitnessPal app to keep calories at a healthy level while getting about 100 grams of protein a day. 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