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A diet that is severely restricted in carbohydrates often excludes or drastically reduces the intake of vegetables, fruits, and whole cereals while substantially raising the consumption of animal-derived foods. Although highly acknowledged for its beneficial effects on health and in managing chronic conditions, the KD can cause severe health problems if followed without surveillance. Furthermore, KB affects ion channels and neurotransmitter carriers, impacting the glutamate-to-ketone percentage and potentially decreasing epileptic events [27,28]. Changes in lipid metabolism are notable when following the KD, with a common focus on its effects on blood lipids. As non-communicable diseases continue to impose a disproportionate burden, particularly in low- and middle-income countries with over 31.4 million deaths annually , the role of dietary interventions alongside pharmacological treatments gains prominence . Furthermore, the KD, which is characterised by the intake of meals rich in fats, has the potential to impact the pharmacokinetics of specific medications with high lipophilicity, hence enhancing their absorption and bioavailability. For KD, research is warranted into the biological effects of βOHB and whether these might negate health impacts relating to reduced microbial butyrate production. Microbiota-host interactions are complex and the health effects are not fully understood, limiting the health impact interpretation of microbial changes. The included studies lack consistency across factors that may influence microbiota, such as their KD composition, data collection methods, microbial analysis methods, inclusion and exclusion criteria, along with participant characteristics such as age, health, medication, and baseline diet. LPS plasma levels rise as a result of increased intestinal permeability, allowing the flow of gram-negative bacteria, such as Bacteroidetes whose membranes contain LPS, from the intestines into the blood (145, 146). In mice, the link between high-fat diet-induced microbial alterations, including a reduction in Bifidobacterium, and a downstream inflammatory response, specifically cytokines linked to insulin resistance, has been demonstrated (140, 141). Cumulatively, this research suggests that the pattern of microbial alterations following KD adherence, namely decreased Bifidobacterium and Firmicutes butyrate-producing bacteria, may be detrimental to colonic health and potentially increase the risk of colonic diseases. Research has demonstrated high dietary fibre intake increases these bacteria (93). This review’s most striking and conclusive finding relates to KD’s persistent negative impact on Bifidobacterium, which strictly metabolises carbohydrate substrates as its energy source (46, 86). Given the microbiota’s role in the breakdown of NDCs, research has predominantly allocated cause to the reduction in carbohydrate intake (82-84). Animal studies indicate a high-fat diet has a negative impact on microbiota composition (49, 63). Given KD’s extreme alterations to dietary macronutrient ratios, it follows that this diet may instigate shifts in an individual’s microbial composition. Diet type, for example, plant- versus animal-based, as well as specific dietary components, particularly macronutrients, have profound microbial impacts (8, 49, 56). Short-chain fatty acids (SCFAs) such as butyrate, propionate, and acetate are predominant metabolites produced mainly through carbohydrate fermentation by specific species (36, 48). 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