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Most tested the ability of cannabinoids to relieve chronic pain in people with cancer or acute pain following surgery or injury. Many of the medical marijuana advocates who spoke at the public sessions held by the IOM—among them cancer and AIDS patients, migraine sufferers, and people with spastic and movement disorders—described how marijuana helped relieve their painful symptoms (see Chapter 2). However, when glucose is limited, the liver starts to burn fat to generate energy. The pharmacodynamic effects of caffeine depend on its pharmacokinetic properties. 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