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Collection of high-quality RWD will require improvements in patient retention, data monitoring, and more robust data collection methods within a controlled clinical setting. Collection of detailed, accurate product information is a challenge, especially with inhaled products (Corroon et al. 2020). Improved patient retention and more robust, harmonized data collection methods will improve future observational studies and allow for long-term assessment. [4, 5, 6 ] The American College of Obstetricians and Gynecologists (ACOG) recommends that women who are pregnant or contemplating pregnancy should be encouraged to discontinue cannabis use. [1, 2, 3] Based on published animal research, there are also concerns that use of cannabis during pregnancy may negatively impact fetal brain development. However, the use of untested drugs can have unpredictable and unintended consequences. 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