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The study performed by Sato et al. also proved that an increase of chewing time led to a reduction in blood glucose levels after breakfast and boosted insulin secretion . Chewing also enhances the secretion of GLP-1, a protein known to enhance glucose-stimulated insulin secretion . Previous studies have shown that more chewing increases the flow rate of saliva, which is positively correlated with the activity of salivary amylase-alpha. Nevertheless, the results delineated that there was no statistically significant difference in terms of glucose tolerance between men and women after ingesting P-SG and T-SG. Additionally, sex hormones also play a vital role in maintaining glucose homeostasis. Sicree et al. reported that, in the Australian population, women have lower fasting blood glucose levels and higher AUC after OGTT than men . Furthermore, the present study also revealed that women tend to have a significantly lower glucose tolerance than men after ingesting glucose dissolved in water. Gummies with low GI values (P-SG and T-SG) demonstrated a significantly lower AUC than gummies with a high GI value (CG), even though the amount of available carbohydrate was the same in all cases. The above findings suggest that the exposed available carbohydrates in P-SG or T-SG would be slightly hydrolyzed by digestive enzymes, releasing a lower amount of glucose. However, it was found that α-1,4-glycosidase in the human digestive tract could not efficiently decompose the maltitol into glucose. Maltitol is a disaccharide polyol produced by starch hydrolysis and must undergo hydrolysis to become glucose and sorbitol before being absorbed. The results of the in vitro release study that CG did present a significantly higher release of glucose than P-SG and T-SG supported above assumptions. This is confirmed by our study, where we found CG showed a lower hardness, gumminess, and chewiness as compared to P-SG and T-SG, which indicated that it would be easier to break into pieces and release sugar during digestion. Although some research reported that sugar/sweeteners type did not significantly influence textural properties , other research discovered that the type of sugar used would affect hardness levels . Because each kind of gummy was made with the same gum base, their different texture properties may be due largely to the differences in sweetener used in the gummy. Sign up for early access to VIP deals, new products, and more. Our products are formulated so you can choose exactly how you want to feel. All of our products are fully legal under the 2018 Farm Bill. Every gummy contains a strategic blend of 80 mg Cannabidiol (CBD) and 20 mg Cannabinol (CBN). 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