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Both low and high doses (1.98 and 3.56 percent Δ9-THC) of smoked cannabis resulted in significantly higher ratings for these effects. Regular cannabis users also find the effects of oral Δ9-THC to be qualitatively different from those of smoked cannabis (Calhoun et al., 1998). Despite initial support for the efficacy of oral cannabinoid medication, many medicinal cannabis patients prefer to smoke cannabis (Grella et al., 2014; O’Connell & Bou-Matar, 2007). To date, the quality of evidence supportive of cannabinoid treatment for spasticity and chronic pain has been moderate, whereas only low-quality evidence was available to support its use for nausea and vomiting and for weight gain in patients with HIV/AIDS or cancer (for a review, see Whiting et al., 2015). For example, in Colorado in 2014, 1.96 million units of edible medicinal cannabis-infused products and 2.85 million units of edible retail cannabis-infused products were sold, which accounted for about 45 percent of the total cannabis sales in the state (Brohl, Kammerzell, & Koski, 2015). Edibles are food products infused with cannabis extract. In particular, the use of edible cannabis products has been highlighted as an issue of concern, principally in states where cannabis has been legalized (MacCoun & Mello, 2015; Monte et al., 2015). For example, only state residents who have a medicinal cannabis card can legally buy medicinal cannabis in Colorado without minimum age restrictions, but any adult aged 21 and older can purchase retail cannabis products in person from cannabis stores, regardless of state of residence (Monte, Zane, & Heard, 2015; 1 Colo. Code Regs. § 212-1, 2016). 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