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Simultaneously, the growing access to unregulated CBD products, which may be adulterated with potentially toxic compounds, requires regulation and education about CBD for its potential benefits and/or adverse effects in health and disease. Mechanical hyperalgesia was improved by CBD treatment following traumatic brain injury in mice, myofascial pain in rats, and 6-hydroxydopamine-induced mouse model of Parkinson’s disease, however these studies require follow-up to inspect potential mechanisms of action (Belardo et al., 2019; Wong and Cairns, 2019; Crivelaro Do Nascimento et al., 2020). Few preclinical studies have been performed to evaluate the mechanism of analgesia for CBD treatment of chronic pain. CBD topicals can offer relief that lasts up to six hours, depending on bioavailability factors. While CBD cream is commonly used to help with minor aches and pains, we cannot and do not make any medical claims regarding the use of CBD, including its use for arthritis. 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