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Cigarette with 20 mg of CBN and no THC.28 Subjective effects such as fatigue and sedation were not formally assessed, but the authors concluded there were “no psychoactive effects noted” for either route of administration.This study was overseen by Hollister who reported an absence of THC-like effects after orally administering CBN to 6 healthy male volunteers in 1973 and coadministering CBN and THC to 15 healthy male volunteers in 1975. In the same year, Hollister et al. administered oral THC (20 mg) combined with either placebo, CBN (40 mg), or CBD (40 mg) to 15 healthy male volunteers in random order on separate occasions.24 Unlike the Karniol et al. study, CBN did not affect heart rate or subjective drug effects when combined with THC. 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