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Dr Culpepper has served as an advisor or consultant for AstraZeneca, Boehringer-Ingelheim, Elsevier Press, Forest, Janssen, Jazz, Lundbeck A/S, Merck, Pfizer, Reckitt Benckiser, Sanofi-Aventis, Shire PLC, Sunovion, and Takeda; has made presentations regarding a federally funded study of methods to reduce hospital readmissions (with no mention of pharmaceutical agents) supported through Merck’s speakers bureau; owns stock in M3 (My Mood Monitor); and receives royalties from UpToDate and Oxford University Press. The exclusion of these agents should be considered when interpreting the evidence summarized in the present study. In addition to the considerations summarized here regarding the efficacy and tolerability of OTC sleep agents, other concerns may pose significant risk, namely drug-drug interactions (Table 1). Deep Sleep is the most potent cannabis sleep therapy available today, uniquely designed to increase your comfort and provide a better night’s sleep. 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